Rivers United FC (Nigeria) 2-1 Wydad AC (Morocco)
Plateau United FC (Nigeria) 2-1 E.S.T. (Tunisia)
ASN Nigelec (Niger) 0-2 Raja CA (Morocco)
US Monastirienne (Tunisia) 0-1 Al Ahly SC (Egypt)
Vipers SC (Uganda) 0-0 TP Mazembe (DR Congo)
La Passe FC (Seychelles) 0-7 Mamelodi Sundowns (South Africa)
Asec Mimosas (Côte D’Ivoire) – Horoya AC (Guinea)
ASKO De Kara (Togo) 1-2 JS Kabylie (Algeria)
Djoliba AC de Bamako (Mali) 2-1 CR Belouizdad (Algeria)
Young Africans (Tanzania) 1-1 Al Hilal (Sudan)
Al Merrikh (Sudan) 2-0 Al Ahli Tripoli (Libya)
FLAMBEAU DU CENTRE(Burundi) – Zamalek SC (Egypt)
Cape Town City FC (South Africa) 0-3 Atlético Petroleos (Angola)
CD Primeiro de Agosto (Angola) 1-3 Simba SC (Tanzania)
Royal Leopards FC (Eswatini) 1:1 Coton Sport FC (Cameroon)
Rail Club du Kadiogo (RCK) (Burkina Faso) – AS Vita Club (DR Congo)
Source: Confédération Africaine de Football (CAF)